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Daily Brief · 2026-05-14 · 2026-05-14 03:04 UTC
903 articles monitored · 14543 events scored · 2363 high-value · 82 verified sources
14543
Events
14364
Stories
2363
High Value
82
Sources
11342health canada approval
2197ema approval
505m a deal
110anvisa approval
79fda approval
33phase3 result
25regulatory filing
23partnership
23earnings guidance
7trial halt
6fda rejection
6orphan drug
4breakthrough designation
2pdufa
1phase2 result
1unknown
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SOURCES
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FDA, EMA, PubMed, ClinicalTrials.gov, medRxiv, Nature, Lancet, JAMA and more.
⬤ LIVE
Today's biotech landscape was marked by significant regulatory and clinical outcomes. The FDA granted multiple approvals in oncology, including BeOne Medicines' BCL-2 inhibitor sonrotoclax for mantle cell lymphoma and Taiho Oncology's combination therapy for acute myeloid leukemia. In late-stage clinical news, Alkermes reported positive Phase 3 results for its sleep disorder drug Lumryz. Conversely, Gossamer Bio announced the failure of its Phase 3 PROSERA trial, leading to a severe stock decline and subsequent investor lawsuit.
#1
PHASE 3
3.8
Tier A+
Gossamer Bio stock plummets 80% after Phase 3 PROSERA trial failure, triggering lawsuit
The company announced the failure of its Phase 3 PROSERA trial, resulting in an immediate 80% drop in its stock price and the filing of a securities class action lawsuit.
#2
FDA APPROVAL
2.71
Tier A
BeOne Medicines wins accelerated FDA approval for BCL-2 inhibitor sonrotoclax in mantle cell lymphoma
The FDA granted accelerated approval for sonrotoclax for adult patients with r/r MCL after at least two lines of systemic therapy.
#3
PHASE 3
2.78
Tier A
Alkermes' Lumryz meets all endpoints in Phase 3 study for a rare sleep disorder
The drug met all primary and key secondary endpoints in a pivotal Phase 3 study, demonstrating clinical success.
#4
FDA APPROVAL
2.71
Tier A
FDA approves Taiho Oncology's oral combination therapy for newly diagnosed AML
The FDA approved the oral combination for adults aged 75 or older, or those with comorbidities that preclude intensive induction chemotherapy.
#5
FDA APPROVAL
3.84
Tier A+
Partner Therapeutics secures FDA approval for Bizengri in NRG1 fusion-positive cholangiocarcinoma
The drug was approved for adult patients who have progressed on or after prior systemic therapy.
ActionDrugCompanyDetail
Accelerated Approval sonrotoclax (Beqalzi) BeOne Medicines USA, Inc. Approved for adults with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
Approval Inqovi (decitabine and cedazuridine) with venetoclax Taiho Oncology, Inc. Approved for newly diagnosed acute myeloid leukemia (AML) in adults 75 years or older or with comorbidities.
Approval Bizengri Partner Therapeutics Approved for adults with advanced, unresectable or metastatic cholangiocarcinoma with an NRG1 gene fusion who have progressed on prior therapy.
BLA Approval Anbal-cel (CRC01) ProBio Inc. and Curocell BLA regulatory approval for a next-generation anti-CD19 CAR-T therapy.
Approval Famotidine Injection, USP Lupin Limited Received US FDA approval for its Abbreviated New Drug Application (ANDA).
DrugCompanyPhaseResultEndpoints
Lumryz Alkermes Phase 3 Positive Met all primary and key secondary endpoints in a study for a rare sleep disorder.
Seralutinib (from PROSERA trial) Gossamer Bio, Inc. Phase 3 Failure The PROSERA trial failed to meet its endpoints, leading to an 80% drop in stock price.
TypePartiesValueDetail
No deals reported today
The binary risk of Phase 3 readouts was starkly illustrated by Alkermes' success versus Gossamer Bio's catastrophic failure, with immediate and severe market consequences for the latter.
Precision oncology continues its momentum with multiple FDA approvals for targeted therapies (BeOne's BCL-2 inhibitor, Taiho's AML combo, Partner's NRG1 fusion drug), underscoring the value of biomarker-driven development.
The cell therapy field continues to expand globally, with the BLA approval for ProBio/Curocell's CAR-T therapy from Korea signaling increased competition and innovation beyond the initial US/EU hubs.
FDA APPROVAL
On May 13, 2026, the FDA granted accelerated approval to sonrotoclax (Beqalzi), a BCL-2 inhibitor from BeOne Medicines USA, Inc. This approval is for adults with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
On May 13, 2026, the FDA granted accelerated approval to sonrotoclax (Beqalzi), a BCL-2 inhibitor from BeOne Medicines USA, Inc. This approval is for adults with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
FDA APPROVAL
The article highlights the impact of TIL therapies on cancer research, noting that the first TIL therapy received FDA approval two years ago. It prompts an inquiry into the current state of the field following this significant regulatory milestone.
The article highlights the impact of TIL therapies on cancer research, noting that the first TIL therapy received FDA approval two years ago. It prompts an inquiry into the current state of the field following this significant regulatory milestone.
FDA APPROVAL
Lupin Limited announced on May 13, 2026, that it received approval from the United States Food and Drug Administration (FDA) for its Famotidine Injection, USP. This approval marks a significant regulatory milestone for the global pharmaceutical leader.
Lupin Limited announced on May 13, 2026, that it received approval from the United States Food and Drug Administration (FDA) for its Famotidine Injection, USP. This approval marks a significant regulatory milestone for the global pharmaceutical leader.
FDA APPROVAL
On May 13, 2026, the FDA approved an oral combination of decitabine and cedazuridine tablets (Inqovi, Taiho Oncology, Inc.) with venetoclax. This approval is for the treatment of newly diagnosed acute myeloid leukemia (AML) in adults 75 years or older, or those with comorbidities.
On May 13, 2026, the FDA approved an oral combination of decitabine and cedazuridine tablets (Inqovi, Taiho Oncology, Inc.) with venetoclax. This approval is for the treatment of newly diagnosed acute myeloid leukemia (AML) in adults 75 years or older, or those with comorbidities.
PHASE 3
Alkermes announced that its sodium oxybate drug, Lumryz, met all primary and key secondary endpoints in a Phase 3 study for a rare sleep disorder. This clinical success follows Alkermes' $2.37 billion acquisition of Avadel.
Alkermes announced that its sodium oxybate drug, Lumryz, met all primary and key secondary endpoints in a Phase 3 study for a rare sleep disorder. This clinical success follows Alkermes' $2.37 billion acquisition of Avadel.
FDA APPROVAL
This article describes a compilation of New Molecular Entity (NME) drug and new biologic approvals by the Center for Drug Evaluation and Research (CDER). The dataset covers approvals from 1985 to 2019, including both small molecule drugs and new biological products.
This article describes a compilation of New Molecular Entity (NME) drug and new biologic approvals by the Center for Drug Evaluation and Research (CDER). The dataset covers approvals from 1985 to 2019, including both small molecule drugs and new biological products.
FDA APPROVAL
Partner Therapeutics has secured FDA approval for Bizengri. The drug is indicated for adults with advanced, unresectable or metastatic cholangiocarcinoma harbouring an NRG1 gene fusion who have progressed on or after prior systemic therapy.
Partner Therapeutics has secured FDA approval for Bizengri. The drug is indicated for adults with advanced, unresectable or metastatic cholangiocarcinoma harbouring an NRG1 gene fusion who have progressed on or after prior systemic therapy.
FDA APPROVAL
ProBio Inc. and Curocell have achieved a significant milestone with the BLA regulatory approval of Anbal-cel (CRC01), a next-generation anti-CD19 CAR-T therapy. This approval highlights Korean innovation and marks commercial readiness for the drug.
ProBio Inc. and Curocell have achieved a significant milestone with the BLA regulatory approval of Anbal-cel (CRC01), a next-generation anti-CD19 CAR-T therapy. This approval highlights Korean innovation and marks commercial readiness for the drug.
PHASE 3
Gossamer Bio, Inc. (GOSS) announced the failure of its Phase 3 PROSERA trial, resulting in an 80% drop in its stock price. Consequently, a securities class action lawsuit has been filed against the company and an executive by Hagens Berman, representing investors who purchased securities between June 16, 2025, and February 20, 2026.
Gossamer Bio, Inc. (GOSS) announced the failure of its Phase 3 PROSERA trial, resulting in an 80% drop in its stock price. Consequently, a securities class action lawsuit has been filed against the company and an executive by Hagens Berman, representing investors who purchased securities between Jun
FDA APPROVAL
The first PROTAC drug has gained FDA approval. This milestone bolsters the ambitions for targeted protein degradation and induced proximity in drug development.
The first PROTAC drug has gained FDA approval. This milestone bolsters the ambitions for targeted protein degradation and induced proximity in drug development.
FDA APPROVAL
The FDA has granted approval for Bizengri (zenocutuzumab-zbco), a drug designed to treat NRG1 fusion-positive cholangiocarcinoma, an ultra-rare and aggressive cancer. This approval represents the seventh under the National Priority Voucher Pilot Program.
The FDA has granted approval for Bizengri (zenocutuzumab-zbco), a drug designed to treat NRG1 fusion-positive cholangiocarcinoma, an ultra-rare and aggressive cancer. This approval represents the seventh under the National Priority Voucher Pilot Program.
TRIAL HALT
Ascendis Pharma has ended the internal development of its IL-2 candidate. This decision signifies a pivot away from oncology expansion. The company had previously considered this asset for accelerated approval.
Ascendis Pharma has ended the internal development of its IL-2 candidate. This decision signifies a pivot away from oncology expansion. The company had previously considered this asset for accelerated approval.
FDA APPROVAL
fda_approval: selinexor — None
TRIAL HALT
Ipsen has discontinued two liver disease drug candidates that were acquired from Albireo in 2023. One of these assets has been entirely set aside following the $952 million acquisition of Albireo.
Ipsen has discontinued two liver disease drug candidates that were acquired from Albireo in 2023. One of these assets has been entirely set aside following the $952 million acquisition of Albireo.
FDA APPROVAL
The FDA granted regular approval to rucaparib (Rubraca) on December 17, 2025. This approval is for adults with deleterious BRCA mutation-associated metastatic castration-resistant prostate cancer (mCRPC) who have been previously treated with an androgen receptor-directed therapy.
The FDA granted regular approval to rucaparib (Rubraca) on December 17, 2025. This approval is for adults with deleterious BRCA mutation-associated metastatic castration-resistant prostate cancer (mCRPC) who have been previously treated with an androgen receptor-directed therapy.
FDA APPROVAL
The FDA granted accelerated approval to rucaparib for the treatment of BRCA-mutated metastatic castration-resistant prostate cancer.
The FDA granted accelerated approval to rucaparib for the treatment of BRCA-mutated metastatic castration-resistant prostate cancer.
FDA APPROVAL
On September 27, 2024, the FDA granted traditional approval to selpercatinib (Retevmo) from Eli Lilly and Company. This approval is for adult and pediatric patients 2 years of age and older with advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation.
On September 27, 2024, the FDA granted traditional approval to selpercatinib (Retevmo) from Eli Lilly and Company. This approval is for adult and pediatric patients 2 years of age and older with advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation.
FDA APPROVAL
The FDA's May docket includes at least five PDUFA dates for regulatory decisions. These decisions pertain to one new product submitted via the 505(b)(2) pathway and four label expansions for existing products.
The FDA's May docket includes at least five PDUFA dates for regulatory decisions. These decisions pertain to one new product submitted via the 505(b)(2) pathway and four label expansions for existing products.
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